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Cancer cell movement and cancer cell invasion inhibitor: T07-135

Monoclonal antibodies that inhibit the activation of cancer cell motility and invasion.

■Introduction of Tohoku University Technology PAR1 (Proteinase activated receptor 1) is a seven-transmembrane receptor that is expressed in most metastatic cancer cells. This invention relates to a monoclonal antibody that inhibits the cleavage of the N-terminal extracellular domain of PAR1, thereby suppressing the motility and invasiveness of cancer cells.

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